Grant Details

High-End Instrumentation Grant Program (S10)

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    Funder Type

    Federal Government

    IT Classification

    B - Readily funds technology as part of an award


    National Institutes of Health (NIH)


    The purpose of this funding opportunity is to continue the High-End Instrumentation (HEI) grant Program administered by ORIP. The objective of the Program is to make available to institutions expensive research instruments that can only be justified on a shared-use basis and that are needed for NIH-supported projects in basic, translational or clinical areas of biomedical/behavioral research. The HEI Program provides funds to purchase or upgrade a single item of expensive, specialized, commercially available instrument or an integrated instrumentation system. An integrated instrumentation system is one in which the components, when used in conjunction with one another, perform a function that no single component could provide. The components must be dedicated to the system and not used independently.

    Types of supported instruments include, but are not limited to: X-ray diffractometers, electron and light microscopes, mass and nuclear magnetic resonance (NMR) spectrometers, protein and DNA sequencers, biosensors, cell sorters, and biomedical imagers. Applications for "stand alone" computer systems (supercomputers, computer clusters and storage systems) will only be considered if the instrument is solely dedicated to the research needs of a broad community of NIH-supported investigators.

    All instruments, integrated systems, and computer systems must be dedicated to research only.

    To promote cost effectiveness, to encourage optimal sharing among individual investigators, research groups and departments, and to foster a collaborative multidisciplinary environment, the instrument should be integrated in a core facility, whenever possible.

    Each applicant institution must propose a Program Director/Principal Investigator (PD/PI) who can assume administrative/scientific oversight responsibility for the requested instrumentation. The PD/PI will be responsible for:

    • Requesting no-cost extensions of the project period, if needed.
    • Preparing (and working with the Institution to submit) a Final Progress Report at the end of the project period that describes the purchased instrument, lists all users and publications resulting from use of the instrument, and outlines the value of the instrument to the investigators and to the institution as a whole. 
    • Preparing and submitting Annual Usage Reports (AURs) of the instrument to the NIH for a period of four years after the project end date.

    The PD/PI and the Advisory Committee are responsible for the development of guidelines for:

    • Maximum utilization of the instrument, including time allocation.
    • A detailed plan for the day-to-day management and safe operation of the instrument.
    • A plan to ensure that access to the instrument is limited to users whose projects have
    • received approval from institutional human subjects, animal welfare, and biosafety committees, as applicable.
    • A financial plan for the long-term operation and maintenance of the instrument during the post-award period.
    • Relocation of the instrument within or outside the institution or change of ownership, if such change is necessary.
    • Recommending a new PD/PI, if such a need arises.

    History of Funding

    None is available.

    Additional Information

    The HEI Program will not support requests for:

    • An instrument with a base cost of less than $600,001;
    • Multiple instruments bundled together;
    • Purely instructional equipment;
    • Institutional administrative management systems, clinical management systems, or instruments to be used purely for clinical (billable) care;
    • Software, unless it is integral to the operation of the requested equipment;
    • General purpose equipment or an assortment of instruments to furnish a research facility and equipment for routine sustaining infrastructure (such as standard machine shop equipment, standard computer networks, autoclaves, hoods, and equipment to upgrade animal facilities).

    Not Allowed: Only accepting applications that do not propose clinical trials.


    Paul Sammak

    Paul Sammak
    National Institute of General Medical Sciences (NIGMS)
    9000 Rockville Pike
    Bethesda, MD 20892

    Karen Brummett

    Karen Brummett
    Office of Research Infrastructure Programs (ORIP)
    9000 Rockville Pike
    Bethesda, MD 20892

  • Eligibility Details

    Eligible applicants are Institutions of Higher Education and Nonprofits other than Institutions of Higher Education. The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
    • Hispanic-serving Institutions;
    • Historically Black Colleges and Universities (HBCUs);
    • Tribally Controlled Colleges and Universities (TCCUs);
    • Alaska Native and Native Hawaiian Serving Institutions; and
    • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

    Deadline Details

    Applications must be submitted June 1, 2021. A similar deadline is anticipated, annually.


    Award Details

    ORIP intends to commit about $30 million in FY 2022 to fund an estimated 25 awards. Applications will be accepted that request a single, commercially available instrument or integrated system. The minimum award is $600,001. There is no upper limit on the cost of the instrument, but the maximum award is $2,000,000. Since the cost of the various instruments will vary, it is anticipated that the size of the award also will vary.

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